With such a small system, maybe they should go for Ukelele Hero instead...
In a recent interview with C|Net, Red Octane co-founder and COO Charles Huang has revealed that a Nintendo DS version of the mega-huge Guitar Hero franchise is currently in development.
We are working on that. We're exploring a lot of things. We're hoping to really bring the experience to the DS and to do some very, very different approaches. We're working through a lot of engineering issues with Nintendo. I actually came from a set of meetings with them last week about this. While the technical path hasn't been set yet, we intend for this to be a very unique experience just like Guitar Hero was on consoles.
Huang goes on to say that he can't reveal much right now, as they are still in talks with Nintendo over the specifics of how the game will work on the DS. They have not even yet decided if they are going to create a Guitar Hero specific peripheral for the system.