| Name |
System |
Subsystem |
Players |
Genre |
Release Date |
| Sally's Salon | Nintendo DS | | 1 | Simulation | Nov 11, 2008 |
| Sands of Destruction | Nintendo DS | | 1 | RPG | Jan 2010 |
| Save the Turtles | Nintendo DS | | 1 | Puzzle | Mar 29, 2010 |
| SBK: Snowboard Kids DS | Nintendo DS | | 1 - 4 | Sports | Nov 2005 |
| Scooby-Doo! and the Spooky Swamp | Nintendo DS | | | | Sep 14, 2010 |
| Scooby-Doo! First Frights | Nintendo DS | | | Action | Sep 2009 |
| Scooby-Doo! Unmasked | Nintendo DS | | 1 | Adventure | Oct 18, 2005 |
| Scrabble | Nintendo DS | | | Party/Parlor | Mar 17, 2009 |
| Scrabble Classic | Nintendo DS | DSiWare | 1 - 4 | Puzzle | Feb 15, 2010 |
| Scrabble Slam! | Nintendo DS | DSiWare | 1 - 4 | Party/Parlor | Apr 26, 2010 |
| Scribblenauts | Nintendo DS | | 1 - 2 | Puzzle | Sep 15, 2009 |
| Scurge: Hive | Nintendo DS | | 1 | Adventure | Oct 24, 2006 |
| Sea Battle | Nintendo DS | DSiWare | 1 - 2 | | Apr 24, 2014 |
| Sea Monsters: A Prehistoric Adventure | Nintendo DS | | | | Oct 25, 2007 |
| SeaWorld: Shamu's Deep Sea Adventures | Nintendo DS | | 1 | Adventure | Nov 8, 2005 |
| Secret Files: Tunguska | Nintendo DS | | | Adventure | May 19, 2009 |
| Sega Casino | Nintendo DS | | 1 - 4 | Party/Parlor | Nov 15, 2005 |
| Sega Superstars Tennis | Nintendo DS | | | Sports | Mar 18, 2008 |
| Shantae: Risky's Revenge | Nintendo DS | DSiWare | | Action | Oct 4, 2010 |
| Shapo | Nintendo DS | DSiWare | 1 | Puzzle | Mar 21, 2011 |
| Shaun the Sheep | Nintendo DS | | | | Q4 2008 |
| Shawn Johnson Gymnastics | Nintendo DS | DSiWare | 1 | Sports | Feb 7, 2011 |
| Shin Megami Tensei | Nintendo DS | | | RPG | TBA |
| Shin Megami Tensei: Devil Survivor | Nintendo DS | | 1 | RPG | Jun 23, 2009 |
| Shin Megami Tensei: Devil Survivor 2 | Nintendo DS | | 1 | | Feb 28, 2012 |
| Shin Megami Tensei: Strange Journey | Nintendo DS | | 1 | RPG | Mar 23, 2010 |
| Shorts | Nintendo DS | | 1 | Action | Aug 18, 2009 |
| Showtime Championship Boxing | Nintendo DS | | | Sports | Oct 29, 2007 |
| Shrek: Ogres and Dronkeys | Nintendo DS | | | Adventure | Oct 30, 2007 |
| Shrek Smash 'N Crash Racing | Nintendo DS | | | Racing | Jan 2007 |
| Shrek SuperSlam | Nintendo DS | | 1 - 4 | Fighting | Oct 25, 2005 |
| Shrek the Third | Nintendo DS | | | Action | May 2007 |
| Sid Meier's Civilization Revolution | Nintendo DS | | | Strategy | Jul 8, 2008 |
| Silverlicious | Nintendo DS | | 1 | Adventure | Mar 20, 2012 |
| SimAnimals | Nintendo DS | | 1 | Simulation | Jan 21, 2009 |
| SimCity Creator | Nintendo DS | | | Simulation | Sep 22, 2008 |
| SimCity DS | Nintendo DS | | | Simulation | Jun 20, 2007 |
| Six Flags: Fun Park | Nintendo DS | | 1 - 4 | Party/Parlor | Oct 21, 2008 |
| Skate It | Nintendo DS | | | Sports | Nov 19, 2008 |
| Slingo Supreme | Nintendo DS | DSiWare | 1 | Puzzle | Dec 29, 2011 |
| Smart Girl's Playhouse Mini | Nintendo DS | DSiWare | 1 | Party/Parlor | Nov 8, 2012 |
| Snakenoid Deluxe | Nintendo DS | DSiWare | 1 | | May 24, 2012 |
| SNK vs. Capcom Card Fighters DS | Nintendo DS | | | Party/Parlor | Year 2006 |
| Snowboard Xtreme | Nintendo DS | DSiWare | 1 | Sports | Jan 3, 2013 |
| Sokomania | Nintendo DS | DSiWare | 1 | Puzzle | May 3, 2010 |
| Sokomania 2: Cool Job | Nintendo DS | DSiWare | 1 | Puzzle | May 8, 2014 |
| Solatorobo: Red the Hunter | Nintendo DS | | 1 | RPG | Sep 27, 2011 |
| Sonic Chronicles: The Dark Brotherhood | Nintendo DS | | | RPG | Sep 30, 2008 |
| Sonic Classic Collection | Nintendo DS | | | Action | Q2 2010 |
| Sonic Colors | Nintendo DS | | | Action | Q4 2010 |
| Sonic DS | Nintendo DS | | | Action | TBA |
| Sonic Rush | Nintendo DS | | 1 | Action | Nov 2005 |
| Sonic Rush Adventure | Nintendo DS | | 1 - 2 | Action | Sep 18, 2007 |
| Sonic & Sega All Stars Racing | Nintendo DS | | | Racing | Feb 2010 |
| Soul Bubbles | Nintendo DS | | 1 | Puzzle | Jul 1, 2008 |
| Spaceball: Revolution | Nintendo DS | DSiWare | 1 | Puzzle | Feb 15, 2010 |
| Space Bust-A-Move | Nintendo DS | | 1 - 4 | Puzzle | Jul 28, 2009 |
| Space Camp | Nintendo DS | | | | May 26, 2009 |
| Space Invaders Extreme | Nintendo DS | | | Shooter | Jun 17, 2008 |
| Space Invaders Extreme 2 | Nintendo DS | | | | Oct 20, 2009 |
| Space Invaders Extreme Z | Nintendo DS | DSiWare | 1 | Shooter | TBA |
| Space Invaders Revolution | Nintendo DS | | 1 | Shooter | TBA |
| Spanish for Everyone | Nintendo DS | | | Party/Parlor | Oct 23, 2007 |
| Sparkle Snapshots | Nintendo DS | | 1 | | Nov 2, 2009 |
| Spectral Force Genesis | Nintendo DS | | | Strategy | Mar 16, 2010 |
| Spectrobes | Nintendo DS | | 1 - 16 | RPG | Mar 13, 2007 |
| Spectrobes: Beyond The Portals | Nintendo DS | | | RPG | Oct 7, 2008 |
| Speed Racer | Nintendo DS | | 1 - 6 | Racing | May 6, 2008 |
| Spelling Challenges and More! | Nintendo DS | | | Puzzle | Sep 25, 2007 |
| Spider-Man 2 DS | Nintendo DS | | 1 | Action | Nov 21, 2004 |
| Spider-Man 3 | Nintendo DS | | 1 | Action | May 2007 |
| Spider-Man: Battle for New York | Nintendo DS | | 1 | Action | Nov 15, 2006 |
| Spider-Man: Edge of Time | Nintendo DS | | | Action | Oct 4, 2011 |
| Spider-Man: Friend or Foe | Nintendo DS | | 1 - 2 | Action | Oct 2, 2007 |
| Spider-Man: Shattered Dimensions | Nintendo DS | | | | Sep 7, 2010 |
| Spider-Man: Web of Shadows | Nintendo DS | | 1 | Action | Oct 21, 2008 |
| Spin Six | Nintendo DS | | 1 | Puzzle | Jun 21, 2010 |
| Spirit Hunters Inc | Nintendo DS | DSiWare | 1 | | Nov 22, 2012 |
| Spitfire Heroes: Tales of the Royal Air Force | Nintendo DS | | 1 | | Feb 25, 2008 |
| SpongeBob Party (DS) | Nintendo DS | | 1 - 4 | Action | TBA |
| SpongeBob's Atlantis SquarePantis | Nintendo DS | | | | Oct 23, 2007 |
| SpongeBob SquarePants: Creature from the Krusty Krab | Nintendo DS | | | Action | Q3 2006 |
| SpongeBob SquarePants: Plankton's Robotic Revenge | Nintendo DS | | | | Oct 22, 2013 |
| SpongeBob SquarePants: The Yellow Avenger | Nintendo DS | | 1 | Action | Nov 7, 2005 |
| Spongebob vs. The Big One: Beach Party Cook-Off | Nintendo DS | | 1 - 4 | Party/Parlor | Mar 3, 2009 |
| Spore Creatures | Nintendo DS | | | Simulation | Sep 7, 2008 |
| Spore Hero Arena | Nintendo DS | | | | Q3 2009 |
| Spot It! Mean Machines | Nintendo DS | DSiWare | 1 - 4 | Puzzle | Nov 1, 2012 |
| Spot It! Mean Machines | Nintendo DS | DSiWare | 1 - 4 | Puzzle | Nov 1, 2012 |
| Spotto! | Nintendo DS | DSiWare | 1 | | Feb 15, 2010 |
| Sprung | Nintendo DS | | 1 | Simulation | Dec 7, 2004 |
| Spyro: Shadow Legacy | Nintendo DS | | 1 | Action | Oct 2005 |
| Squeeballs | Nintendo DS | | | | Q3 2009 |
| Squishy Tank | Nintendo DS | | 1 | Puzzle | Mar 2010 |
| Star Fox Command | DS / WiiU | | 1 - 6 | Shooter | Aug 28, 2006 |
| Starship Defense | Nintendo DS | | 1 | Strategy | Jan 18, 2010 |
| Star Trek: Tactical Assault | Nintendo DS | | 1 - 2 | Strategy | Q3 2006 |
| Star Wars Battlefront: Elite Squadron | Nintendo DS | | 1 - 4 | Action | Nov 3, 2009 |
| Star Wars Ep. III: Revenge of the Sith (DS) | Nintendo DS | | | Action | May 4, 2005 |
| Star Wars: Lethal Alliance | Nintendo DS | | | Action | Dec 13, 2006 |
| Star Wars: The Clone Wars: Jedi Alliance | Nintendo DS | | 1 - 2 | Action | Nov 11, 2008 |
| Star Wars The Clone Wars: Republic Heroes | Nintendo DS | | | Action | Sep 2009 |
| Star Wars: The Force Unleashed | Nintendo DS | | | Action | Sep 16, 2008 |
| Star Wars: The Force Unleashed II | Nintendo DS | | | | Oct 26, 2010 |
| Steal Princess | Nintendo DS | | | Action | May 19, 2009 |
| SteamWorld Tower Defense | Nintendo DS | DSiWare | | | Jul 5, 2010 |
| Steel Horizon | Nintendo DS | | | Strategy | Mar 20, 2007 |
| Stratego: Next Edition | Nintendo DS | DSiWare | 1 - 2 | Strategy | Jun 23, 2011 |
| Strawberry Shortcake: The Four Seasons Cake | Nintendo DS | | | Action | Nov 15, 2007 |
| Style Savvy | DS / WiiU | | 1 - 4 | Simulation | Nov 2, 2009 |
| Sudoku | Nintendo DS | DSiWare | 1 | Puzzle | Oct 26, 2009 |
| Sudoku 4Pockets | Nintendo DS | DSiWare | 1 | Puzzle | Feb 8, 2010 |
| Sudoku Challenge! | Nintendo DS | DSiWare | 1 | Puzzle | Nov 30, 2009 |
| Sudoku Gridmaster | Nintendo DS | | 1 | Puzzle | Jun 26, 2006 |
| Sudoku Master | Nintendo DS | | 1 | Puzzle | Jun 29, 2009 |
| Sudoku Sensei | Nintendo DS | DSiWare | 1 | Puzzle | Dec 28, 2009 |
| Sudoku Student | Nintendo DS | DSiWare | 1 | Puzzle | Jul 27, 2009 |
| Suikoden Tierkreis | Nintendo DS | | | | Mar 17, 2009 |
| Summon Night: Twin Age | Nintendo DS | | | RPG | Jun 3, 2008 |
| Super Black Bass Fishing | Nintendo DS | | 1 - 4 | Sports | Mar 28, 2006 |
| Super Collapse! 3 | Nintendo DS | | | Puzzle | Oct 16, 2007 |
| Super Dodgeball Brawlers | Nintendo DS | | | Sports | May 27, 2008 |
| Superman Returns: The Videogame | Nintendo DS | | 1 | Action | Nov 20, 2006 |
| Super Mario 64 DS | DS / WiiU | | 1 - 4 | Action | Nov 21, 2004 |
| Super Monkey Ball Touch & Roll | Nintendo DS | | | Action | Mar 2006 |
| Super Princess Peach | Nintendo DS | | 1 | Action | Feb 27, 2006 |
| Super Robot Taisen OG Saga: Endless Frontier | Nintendo DS | | | RPG | Apr 28, 2009 |
| Super Scribblenauts | Nintendo DS | | 1 | Puzzle | Q3 2010 |
| Super Swap | Nintendo DS | DSiWare | 1 | Puzzle | Jun 21, 2010 |
| Super Yum Yum Puzzle Adventures | Nintendo DS | DSiWare | 1 | Puzzle | Mar 29, 2010 |
| Surfacer+ | Nintendo DS | DSiWare | 1 | Puzzle | Jan 10, 2011 |
| Surf's UP | Nintendo DS | | 1 - 2 | Sports | Q3 2007 |
| Surviving High School | Nintendo DS | DSiWare | 1 | | Apr 19, 2010 |
| Sushi Academy | Nintendo DS | | | Party/Parlor | Jun 15, 2009 |
| Sushi Go Round | Nintendo DS | | 1 | Puzzle | Mar 30, 2010 |
| Suzuki Super Bikes Riding Challenge | Nintendo DS | | | Sports | Aug 2007 |
| Syberia | Nintendo DS | | | Adventure | Dec 2, 2008 |
| System Flaw | Nintendo DS | | 1 | Shooter | Oct 27, 2009 |
| System Flaw Recruit | Nintendo DS | DSiWare | 1 | Shooter | Apr 26, 2010 |
