Read: New 3DS and Amiibo
For hardware, as mentioned the big mover is the $99 US New 3DS. It doesn't come with any games, but it looks to be a common seller throughout the rest of the year at least. There may also be some new stock of the NES Classic, but that will not last long if initial stock numbers are any indication.
Due to the limited supply - and demand - for the Wii U, there's no repeat of the Smash Splat bundle from last year. In fact, there's nobody selling the Wii U at a discount at all that we were able to locate. The only other home console deal we could locate is GameStop selling pre-owned Wiis for $40.
Best Buy appears to be the big winner on the accessory front: they're advertising a $10 Lucina amiibo for Black Friday, and if you want to load up on the eShop credit they're offering $50 cards for $40 or 15% off eShop cards. One big caveat with Best Buy: Gamer's Club Unlocked discounts do NOT apply on Black Friday. Amazon's 20% off for Prime members around launch appears to, but that would only really apply to Pokémon Sun and Moon.
UPDATE: BlackNMild2k1 on the NWR forums spotted a 200GB microSD card with adapter for $49.99, which can work with the New 3DS. Or maybe the Switch.
Thankfully, the software front will have some things to look forward to.